New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides.

نویسندگان

  • Dexing Zeng
  • Qin Ouyang
  • Zhengxin Cai
  • Xiang-Qun Xie
  • Carolyn J Anderson
چکیده

A new cross-bridged cyclam chelator, CB-TE1K1P, was developed for copper-based radiopharmaceuticals, and this chelator can be labelled with (64)Cu under mild conditions in high specific activity. DBCO-PEG4-CB-TE1K1P was synthesized for conjugation to proteins, while Dde-CB-TE1K1P((t)Bu2)-OH was synthesized for solid-phase peptide synthesis. Examples of the conjugation chemistry, radiolabelling and serum stability of each are presented.

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عنوان ژورنال:
  • Chemical communications

دوره 50 1  شماره 

صفحات  -

تاریخ انتشار 2014